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With the normalization of the COVID-19 pandemic prevention and control, there is an urgent need to develop a healthy urban public space. However, because of the fast urbanization process with a series of problems, such as PM2.5 air pollution, the Urban Heat Island, and the relatively high frequency of static winds under the influence of its topography, the ventilation problem in the public spaces of Chengdu is of great importance. Along these lines, in this work, the history of theoretical research on urban ventilation is summarized and reviewed first to evaluate the urban wind environment. Second, so far, qualitative methods are mainly adopted for the evaluation methods of microclimate adaptation. However, the practical application has achieved few results. Meanwhile, there is still a lack of comprehensive and unified research on the multi-element of human microclimate comfort in public space. For this reason, the urban ventilation assessment system was established in this work according to the physical, physiological, and psychological aspects, with 9 indices selected and ranked. Then, an optimization strategy for rebuilding the urban public space was proposed for improving the wind environment microclimate adaption on three levels: macro city-regional level, meso block linear space, and micro space node. By taking Eastern Banlieue Memory Industrial Park as an example, the statistical data were systematically investigated on the spot from the results of 249 wind environment questionnaires, and 30 Delphi expert consultation questionnaires. Combined with the Computational Fluid Dynamics (CFD) simulation, the results reveal that most public spaces in the study area were below 0.6 m/s in more than 80% of the public space, and wind-based environmental problems obviously exist without any ventilation improvement measures. Combined with the background of the carbon peak era, the ventilation environment of the urban public space is not conducive to using active ventilation equipment. The solution of a complete set of regional intelligent ventilation systems was thoroughly discussed here, while some innovative sustainable systematic solutions and urban ventilation furniture combined with a geothermal heat pump and cloud data platform were formulated.
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Objective To investigate the dynamic changes and clinical significance of specific antibodies in patients with coronavirus disease 2019 (COVID-19). Methods A retrospective study was conducted to collect 141 adult COVID-19 survivors who were followed up in the Eighth Hospital affiliated to Guangzhou Medical University from February 6, 2020, to March 24, 2021. The patients were divided into severe group (severe and critical) and non-severe group (light and ordinary) according to the diagnosis at discharge. The antibody changes of the two groups were compared and analyzed at 1 week, 2 weeks, 1 month, 3 months, 6 months and 1 year after discharge. Results After discharge from hospital, the positive rate of IgG in the severe group was 95.00% after 1 week and 100.00% in the following year, in the positive rate of IgG in the non-severe group was 59.50% after 1 week, 90.08% in 6 months and 76.03% in one year. The level of serum IgG in the severe group was significantly higher than that in non-severe group (Z=-2.441, P=0.015). One-year follow-up: the serum IgG in the severe group was significantly higher than that in the non-severe group (Z=-3.410, P=0.001). The serum IgM level of the severe group after one year follow-up was lower than that of the six months follow-up, the difference was statistically significant (Z=-2.259, P=0.024). The serum IgG and IgM level of the non-severe group after one year follow-up was lower than that of the six months follow-up, the difference was statistically significant (Z=-7.37, P<0.01;Z=3.850, P<0.01). Conclusion The level of serum protective antibody in COVID-19 patients remained high within 6 months after discharge, and remained stable within 1 year after discharge. The antibody titers in the severe group were significantly higher than those in the non-severe group and lasted for at least one year. COVID-19 survivors receive 1 year of natural immune protection, and patients with critical conditions receive immunity for longer periods of time. © 2022 The authors.
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Objective: Shiwei Qingwen decoction (SWQWD) is effective in preventing COVID-19. This study examined the active components of SWQWD and its potential targets for preventing COVID-19. The study used network pharmacology and molecular docking technology to verify the role of SWQWD targets through animal experiments and explored the mechanisms that enhance immunity to alleviate mild COVID-19 symptoms. Methods: First, SWQWD- and COVID-19-related targets were retrieved from TCMSP, GeneCards, and OMIM databases. Second, protein-protein interaction networks were established using the String database. The drug active ingredient target network was constructed in Cytoscape to identify the core target proteins. Third, Gene Ontology (GO) Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to predict the SWQWD mechanism of action. Finally, the targets were validated by molecular docking in an acute lung injury (ALI) rat model. Results: The SWQWD compound target network contained 79 compounds and 277 targets, coinciding with the 73 targets of COVID-19. The most important gene in the core subnetwork was a tumor necrosis factor (TNF). The 3 most potent compounds, quercetin, kaempferol, and luteolin, can enter the active pockets of TNF and have potential therapeutic roles in COVID-19. Conclusion: Quercetin, kaempferol, and luteolin in SWQWD may enhance immunity by regulating multiple TNF signal pathways. After administering SWQWD, the content of tumor necrosis factor-alpha was significantly reduced in the bronchoalveolar lavage fluid (BALF) of ALI rats in comparison to the model group. We believe SWQWD is able to prevent and control COVID-19 through the target of TNF.
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Objective To explore the lag effect of daily average temperature on the incidence of coronavirus disease 2019 (COVID-19) in Hunan Province and to provide scientific evidences for effective prevention of COVID-19. Methods The meteorological factors, the air quality factors and the data conincidence of COVID-19 reported in Hunan Province during January 21, 2020 to March 2, 2020 were collected. Spearman correlation and distributed lag non-linear model analysis were performed. Results A total of 1 018 COVID-19 cases were reported in Hunan Province. The distribution lag non-linear model results showed that the influence of daily average temperature on the incidence of COVID-19 presented a nonlinear relationship. The cumulative relative incidence risk of COVID-19 decreased with the increase of daily average temperature, and the lowest temperature risk of the patients was 0 ℃. Both cold temperature and hot temperature increased incidence risk of COVID-19. It was indicated that the hot effects were immediate, however, the cold effects with obvious lag effect persisted up to 12 days. The highest relative risk of COVID-19 incidence was associated with lag 8-day daily average temperature of -5 ℃(RR=2.20, 95% CI=1.16-4.19). The influence of high temperature(10 ℃) was more significant than that of low temperature(6 ℃). Conclusion The daily average temperature, especially cold or hot temperature, was an important influencing factor of the incidence of COVID-19 in Hunan Province, which had lag influence on the incidence of COVID-19. We suggested that some related preventive measures should be adopted to protect vulnerable population and severe patients to reduce the incidence risk. © 2021, Publication Centre of Anhui Medical University. All rights reserved.
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COVID-19 pandemic has profoundly changed many aspects of Chinese society. In the education field, the alternative online education system functions not only as a timely substitution but also as a new direction. This article examines the evaluation of online education systems by using the contents of blogs about online courses that are shared on Weibo China's social media network. By exploring the blogs' emotional tendency, this article aims to describe the characteristics of alternative online education systems in the events of risks and to discuss optimized programs for future online education.
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The novel coronavirus (the following is named COVID-19) epidemic in 2020 has greatly stimulated the development of "stay-at-home economy", and then affected the business pattern of all walks of life. During the epidemic, people were forced to be quarantined, which greatly increased the time of staying at home, offline demand quickly shifted to online. Users' habits and behavior of short video platform changed greatly, "short video + live", "short video + e-commerce" ,"short video + social" and other operation combination forms developed rapidly. Based on the special factors of epidemic stay-at-home economy, this paper studies the changes of users' behavior and habits brought by epidemic stay-at-home economy and analyzes the effects of these variables on "short video +" industry content generation mode, one of the important components of MCN (multi-channel Network) mode. It is concluded that "short video +" industry content generation mode has moved from PGC (professional production content), OGC (occupationally production content), UGC (user production content) to PUGC (professional user production content) based, plus 3C drive together. At the same time, combined with the current industry hot cases, analyze and promote the new "short video +" industrial chain business model, which will continue works for a long time from content production to operation, to user acquisition, then to commercial realization even after the end of the epidemic in the future.
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While all higher education was affected by the COVID-19 pandemic, study abroad programs were uniquely challenged by the associated restrictions and limitations. This case study integrates a Collaborative Online International Learning (COIL) pedagogy approach and virtual reality (VR) technologies into the curriculum redesign process to transform a business study abroad course into an online format. Using VR technology, U.S. students and their international partners in Germany, Brazil, and India created and shared cultural exchange virtual tours. The redesigned online study abroad course engaged students in active learning activities and cultivated students' intercultural competence development.
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Endotracheal intubation is an independent risk factor for respiratory infectious diseases. We conducted a retrospective study in 12 cases with COVID-19 who underwent endotracheal intubation at ICU of the Guangzhou eighth hospital from January 20 to February 10, 2020. The intubation procedure, anesthetic regimen, and complication were collected and analyzed. The 9 healthcare workers who involved in intubation received virus nucleic acid test and 14 days temperature monitoring. All 12 patients were successfully intubated under the guidance of bronchoscope, without any complications. Midazolam, Propofol and Morphine or fentanyl were used for sedation and analgesia, avoiding patients cough and agitated during the procedure. The 9 healthcare workers were protected under the Personal Protective Equipment(PPE) with positive pressure protective hood. The detection of oropharyngeal swab virus nucleic acid were negative in all 9 healthcare workers, none of them had fever or any respiratory symptoms. The PPE with positive pressure protective hood should be needed to perform bronchoscope-guided endotracheal intubation in patients with COVID-19, it could strengthen to protect healthcare workers from virus exposure.
Subject(s)
Bronchoscopes , Coronavirus Infections/therapy , Intubation, Intratracheal , Personal Protective Equipment , Pneumonia, Viral/therapy , Betacoronavirus , COVID-19 , China , Coronavirus Infections/prevention & control , Humans , Infection Control , Intensive Care Units , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Retrospective Studies , SARS-CoV-2ABSTRACT
The rapid spread of the coronavirus disease 2019 (COVID-19) has become a global threat. But the pathogenesis and treatment of the disease are not clear yet. Virological researches revealed close relationship between 2019-nCoV and SARS-CoV. The experience and knowledge we gained from severe acute respiratory syndrome (SARS), especially with regard to the time course of viral replication, host immune response and clinical progression of the patient, may provide important insights into understanding and management of COVID-19. Clinical deterioration accompanied by decreasing viral load in the second week after symptom onset was noted both in SARS and COVID-19, suggesting that the lung damage at this phase is more related to excessive host immune response rather than uncontrolled viral replication.
Subject(s)
Coronavirus Infections/therapy , Coronavirus Infections/virology , Pneumonia, Viral/therapy , Pneumonia, Viral/virology , Severe Acute Respiratory Syndrome/therapy , Severe Acute Respiratory Syndrome/virology , Severe acute respiratory syndrome-related coronavirus , Betacoronavirus , COVID-19 , Coronavirus Infections/immunology , Disease Progression , Humans , Pandemics , Pneumonia, Viral/immunology , SARS-CoV-2 , Severe Acute Respiratory Syndrome/immunology , Viral Load , Virus ReplicationABSTRACT
Objective: To analyze the clinical characteristics of the severe or critically ill patients with novel coronavirus pneumonia (COVID-19), and evaluate the impact of complicated myocardial injury on the prognosis of these patients. Methods: A retrospective study was conducted in 54 patients who admitted to Tongji hospital from February 3, 2020 to February 24, 2020 and met the criteria of severe or critical conditions of COVID-19. The clinical characteristics and hospital mortality rate were analyzed and compared between the patients with or without myocardial injury, which was defined with 3 times higher serum cardiac troponin value. Results: The age of the 54 patients was 68.0(59.8, 74.3) years. Among all the patients, 24 (44.4%) patients were complicated with hypertension, 13 (24.1%) with diabetes, 8 (14.8%) with coronary heart disease, and 3 (5.6%) with previous cerebral infarction. During hospitalization, 24 (44.4%) of the patients were complicated with myocardial injury and 26 (48.1%) patients died in hospital. In-hospital mortality was significantly higher in patients with myocardial injury than in patients without myocardial injury (14 (60.9%) vs. 8 (25.8%), P=0.013). Moreover, the levels of C-reactive protein (153.6 (80.3, 240.7) ng/L vs. 49.8 (15.9, 101.9) ng/L) and N-terminal pro-B-type natriuretic peptide (852.0 (400.0, 2 315.3) ng/L vs. 197.0 (115.3, 631.0) ng/L) were significantly higher than patients without myocardial injury (all P<0.01). Conclusions: Prevalence of myocardial injury is high among severe or critically ill COVID-19 patients. Severe or critically ill COVID-19 patients with myocardial injury face a significantly higher risk of in-hospital mortality. The study suggests that it is important to monitor and manage the myocardial injury during hospitalization for severe or critically ill COVID-19 patients.